History

From Soviet biochemistry to institutional formalization.

Five decades of research, four eras, one continuous lineage.

The history of endogenic pharmacology — five decades of bioregulator research

In This Section

Four eras of the lineage.

1971 — 1989

Origins

The Soviet-era biochemistry programs that isolated and characterized the original short peptide bioregulators. The hypothesis of endogenous regulatory pool restoration as a therapeutic strategy.

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1990 — 2010

Institutionalization

The establishment of the Saint Petersburg Institute of Bioregulation and Gerontology and parallel research programs across Eastern Europe. Clinical observation, in-vivo replication, longevity studies.

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2011 — 2024

Mechanistic Resolution

The molecular-biology era — chromatin interaction, gene-expression modulation, telomerase regulation. International peer-reviewed replication across Italy, South Korea, and the United Kingdom.

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2026 — Forward

Formalization

The codification of endogenic pharmacology as a formal discipline — the proprietary Ac-X-NH2 modification, the patent portfolio, the opticeutical and endoceutical distribution tiers, and the canonical reference at this institution.

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